B6N.Cg-Igf1tm1Arge/Cnbc
| Status | Available to order |
| EMMA ID | EM:12459 |
| Citation information | RRID:IMSR_EM:12459 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N.Cg-Igf1tm1Arge/Cnbc |
| Alternative name | C57Bl/6 Igf-1 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Igf1tm1Arge |
| Gene/Transgene symbol | Igf1 |
Information from provider
| Provider | Carlos Vicario Abejón |
| Provider affiliation | Instituto Cajal-CSIC |
| Additional owner | Argiris Efstratiadis, M.D., Ph.D., Scientific Director, Biomedical Research Foundation, Academy of Athens,, Greece |
| Genetic information | A portion of exon 4 of the Igf1 gene was replaced by a neo cassette resulting in the elimination of residues 51-70 in the poly-peptide chain. |
| Phenotypic information | Homozygous:All the homozygous C57BL/6 Igf1 knock-out mice die at birth. They show reduced size compared to wild-type and heterozygous mice. All brain structures are formed although the differentiation, migration and positioning of olfactory bulb neurons is altered. Heterozygous:The heterozygous mice appear to be normal. |
| Breeding history | C57BL/6 Igf1 mice were obtained by backcrossing the MF1-crossed mice (Liu et al., 1993, doi: 10.1016/S0092-8674(05)80084-4; see EMMA strain EM:13159) onto a C57BL/6N background for more than 10 times. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6N males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Growth delay due to insulin-like growth factor type 1 deficiency / Orphanet_73272
Literature references
- IGF-I promotes neuronal migration and positioning in the olfactory bulb and the exit of neuroblasts from the subventricular zone.;Hurtado-Chong Anahí, Yusta-Boyo María J, Vergaño-Vera Eva, Bulfone Alessandro, de Pablo Flora, Vicario-Abejón Carlos, ;2009;The European journal of neuroscience;30;742-55; 19712103