B6.129S2-Rr152tm2Cog/Orl
| Status | Available to order |
| EMMA ID | EM:01256 |
| Citation information | RRID:IMSR_EM:01256 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-Rr152tm2Cog/Orl |
| Alternative name | Smu del |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Rr152tm2Cog |
| Gene/Transgene symbol | Rr152 |
Information from provider
| Provider | Ahmed Amine KHAMLICHI |
| Provider affiliation | CNRS UMR 5089 - IPBS |
| Genetic information | Targeting construct is derived from 129 DNA. The deletion spans all the known repeats in the Emu-Cmu intron leaving intact the necessary elements for accurate splicing of mu transcripts. Rr152: cluster regulatory region 152 of mouse Igh gene. |
| Phenotypic information | Decreased class switching to all immunoglobulin isotypes. |
| Breeding history | Crossed to C57BL/6 for several generations. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Literature references
- Immunoglobulin class-switch recombination in mice devoid of any S mu tandem repeat.;Khamlichi Ahmed Amine, Glaudet Florence, Oruc Zeliha, Denis Vincent, Le Bert Marc, Cogné Michel, ;2004;Blood;103;3828-36; 14962903