B6;CBA-Tg(HDexon1)62Gpb/450AjfmH
| Status | Available to order |
| EMMA ID | EM:12703 |
| Citation information | RRID:IMSR_EM:12703 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;CBA-Tg(HDexon1)62Gpb/450AjfmH |
| Alternative name | R6/2_450 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(HDexon1)62Gpb |
| Gene/Transgene symbol | Tg(HDexon1)62Gpb |
Information from provider
| Provider | Jenny Morton |
| Provider affiliation | University of Cambridge |
| Genetic information | One of an allelic series of R6/2 transgenic mice with a CAG repeat of 450 |
| Phenotypic information | Homozygous:We have not bred for homozyosity.Heterozygous:The mice have no overt phenotype. Htt-positive aggregates are present in the brain. |
| Breeding history | 51 generations. This line arose spontaneously from an R6/2 line with a CAG repeat of 250. It has been maintained by crossing onto wild-type (C57BL/6 x CBA)F1 females. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Paradoxical delay in the onset of disease caused by super-long CAG repeat expansions in R6/2 mice.;Morton A Jennifer, Glynn Dervila, Leavens Wendy, Zheng Zhiguang, Faull Richard L M, Skepper Jeremy N, Wight James M, ;2009;Neurobiology of disease;33;331-41; 19130884