C57BL/6N-Styk1tm1e(KOMP)Wtsi Tyrc-2J/Biat
| Status | Available to order |
| EMMA ID | EM:12719 |
| Citation information | RRID:IMSR_EM:12719 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Styk1tm1e(KOMP)Wtsi Tyrc-2J/Biat |
| Alternative name | STOCK-Styk1tm1e(KOMP)Wtsi Tyrc-2J |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Styk1tm1e(KOMP)Wtsi |
| Gene/Transgene symbol | Styk1 |
Information from provider
| Provider | Immo Prinz |
| Provider affiliation | Institute of Immunology, Hannover Medical School |
| Additional owner | Organization: Mouse Biology Program, University of California, Davis Contact Name: Renee S. Araiza Center for Comparative Medicine, One Shields Avenue, Davis, CA 95616 USA |
| Genetic information | The gene Styk1 (MGI:2141396) was targeted (non-conditionally) by homologous recombination. Since there was a backcross with albino (Wtsi-Tyrc-2J) mice, the Styk1tm1e(KOMP)Wtsi/Tyrc-2J mice could possibly be heterozygous for the albino gene. |
| Phenotypic information | Homozygous:Homozygous Styk1 knock-out mice show no other phenotype than wild-type mice.Heterozygous:Heterozygous Styk1 knock-out mice show no other phenotype than wild-type mice. |
| Breeding history | One backcross with albino-B6 (C57BL/6N background) mice; 6 generations of sub-matings have been performed on the C57BL/6N background. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | heterozygous C57BL/6N males |
Literature references
- Styk1 is specifically expressed in NK1.1+ lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function.;Wilharm Anneke, Sandrock Inga, Marotel Marie, Demera Abdi, Naumann Ronald, Walzer Thierry, Prinz Immo, ;2019;European journal of immunology;49;686-693; 30758858