B6;129-Nkx1-1tm1Tlu/Ieg
| Status | Available to order |
| EMMA ID | EM:12749 |
| Citation information | RRID:IMSR_EM:12749 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Nkx1-1tm1Tlu/Ieg |
| Alternative name | Sax2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nkx1-1tm1Tlu |
| Gene/Transgene symbol | Nkx1-1 |
Information from provider
| Provider | Ruth Simon |
| Provider affiliation | Institute of Molecular and Cellular Anatomy, Ulm University |
| Genetic information | The loss-of-function Nkx1.1 (Sax2) mouse line was generated by inserting an IRES-lacZ/floxed neo cassette into BspEI sites of the second exon and second intron (Simon and Lufkin, Mol Cell Biol, 2003, 23:9046-60). |
| Phenotypic information | Homozygous:Sax2 expression occurs in the brain stem. Ablation of Sax2 leads imbalance of energy homeostasis.Heterozygous:Hetero/hemizygous mice do not exhibit an obvious phenotype. |
| Breeding history | The mouse line was kept by interbreeding since its generation in 2001. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6J males |
Literature references
- Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis.;Simon Ruth, Lufkin Thomas, Bergemann Andrew D, ;2007;Developmental dynamics : an official publication of the American Association of Anatomists;236;2792-9; 17879320
- Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.;Simon Ruth, Lufkin Thomas, ;2003;Molecular and cellular biology;23;9046-60; 14645517
- Ablation of Sax2 gene expression prevents diet-induced obesity.;Simon Ruth, Britsch Stefan, Bergemann Andrew, ;2011;The FEBS journal;278;371-82; 21126319