C57BL/6N-Atm1Brd Mir211tm1Wtsi/H
| Status | Available to order |
| EMMA ID | EM:12803 |
| Citation information | RRID:IMSR_EM:12803 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Atm1Brd Mir211tm1Wtsi/H |
| Alternative name | miR-211 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mir211tm1Wtsi |
| Gene/Transgene symbol | Mir211 |
Information from provider
| Provider | Haydn Prosser |
| Provider affiliation | Mouse Genomics (No longer exists), Wellcome Trust Sanger Institute |
| Genetic information | Knockout was made in JM8 ES cells on C57BL/6NTac background. The miR-211 knockout mouse line (mmu-mir-211-/-) obtained by deleting 160 bp (containing the pre-miR-211) from the wild type sequence. |
| Phenotypic information | Homozygous:Progressive retinal cone dystrophy. Seizures were witnessed in some mice.Heterozygous:Unknown. |
| Breeding history | Knockout made in JM8 ES cells on C57BL/6NTac background and maintained on this background by breeding. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- MiR-211 is essential for adult cone photoreceptor maintenance and visual function.;Barbato Sara, Marrocco Elena, Intartaglia Daniela, Pizzo Mariateresa, Asteriti Sabrina, Naso Federica, Falanga Danila, Bhat Rajeshwari S, Meola Nicola, Carissimo Annamaria, Karali Marianthi, Prosser Haydn M, Cangiano Lorenzo, Surace Enrico Maria, Banfi Sandro, Conte Ivan, ;2017;Scientific reports;7;17004; 29209045
- A resource of vectors and ES cells for targeted deletion of microRNAs in mice.;Prosser Haydn M, Koike-Yusa Hiroko, Cooper James D, Law Frances C, Bradley Allan, ;2011;Nature biotechnology;29;840-5; 21822254