STOCK Loxl2^tm1.2Acan/2AcanCnbc

Status	Available to order
EMMA ID	EM:12916
Citation information	RRID:IMSR_EM:12916 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	STOCK Loxl2^tm1.2Acan/2AcanCnbc
Alternative name	Q
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Loxl2^tm1.2Acan
Gene/Transgene symbol	Loxl2

Information from provider

Provider	Amparo Cano
Provider affiliation	Biochemistry, Autonoma University (Medicine Faculty)
Additional owner	Francisco Portillo and Alberto Martin, Universidad Autónoma de Madrid, Spain.
Genetic information	Constitutive Loxl2 knock-out.
Phenotypic information	Homozygous: Partial perinatal lethality due to cardiac and liver defects. Knock-out mice develop a lower number of skin tumors after being subjected to DMBA/TPA (dimethylbenz-anthracene and 12-O-tetradecanoyl phorbol-13-acetate) treatment. Heterozygous: Completely normal.
Breeding history	Obtained as CFB strain (EM:12882) from a different ES clone (#10).
References	Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.;Martin Alberto, Salvador Fernando, Moreno-Bueno Gema, Floristán Alfredo, Ruiz-Herguido Cristina, Cuevas Eva P, Morales Saleta, Santos Vanesa, Csiszar Katalin, Dubus Pierre, Haigh Jody J, Bigas Anna, Portillo Francisco, Cano Amparo, ;2015;The EMBO journal;34;1090-109; 25759215
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archiving	heterozygous mixed males, wild-type FVB/N females
Stage of embryos	2-cell

Disease and phenotype information

IMPC phenotypes (gene matching)

preweaning lethality, incomplete penetrance / IMPC

Literature references

Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.;Martin Alberto, Salvador Fernando, Moreno-Bueno Gema, Floristán Alfredo, Ruiz-Herguido Cristina, Cuevas Eva P, Morales Saleta, Santos Vanesa, Csiszar Katalin, Dubus Pierre, Haigh Jody J, Bigas Anna, Portillo Francisco, Cano Amparo, ;2015;The EMBO journal;34;1090-109; 25759215

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Right strain for your research?

The information provided on this page is, to the best of EMMA’s knowledge, based on data supplied by the original provider. End users are responsible for reviewing these details and for validating the strain and its suitability for their experimental use.
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STOCK Loxl2tm1.2Acan/2AcanCnbc