IMPC phenotypes (gene matching)
- preweaning lethality, incomplete penetrance / IMPC
STOCK Loxl2tm1.1Acan/Cnbc
| Status | Available to order |
| EMMA ID | EM:13005 |
| Citation information | RRID:IMSR_EM:13005 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Loxl2tm1.1Acan/Cnbc |
| Alternative name | AKB |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Loxl2tm1.1Acan |
| Gene/Transgene symbol | Loxl2 |
Information from provider
| Provider | Amparo Cano |
| Provider affiliation | Biochemistry, Autonoma University (Medicine Faculty) |
| Additional owner | Francisco Portillo and Alberto Martin, Universidad Autónoma de Madrid, Spain. |
| Genetic information | Loxl2 conditional knock-out. |
| Phenotypic information | Homozygous:Normal; no remarkable phenotype.Heterozygous:Normal; no remarkable phenotype. |
| Breeding history | Conditional knock-out mutation of Loxl2 based on cre/loxP system was introduced by homologous recombination in the endogenous locus of Loxl2. Positive ES clones for the mutation were microinjected/aggregated into receptive blastocysts/morulas and chimeras were obtained. These animals were crossed with wild-type mice in order to check germline transmision. The resultant heterozygous animals harbouring the conditional knock-out mutation were intercrossed and homozygous animals were obtained. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous mixed males, homozygous mixed females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.;Martin Alberto, Salvador Fernando, Moreno-Bueno Gema, Floristán Alfredo, Ruiz-Herguido Cristina, Cuevas Eva P, Morales Saleta, Santos Vanesa, Csiszar Katalin, Dubus Pierre, Haigh Jody J, Bigas Anna, Portillo Francisco, Cano Amparo, ;2015;The EMBO journal;34;1090-109; 25759215
- Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer.;Salvador Fernando, Martin Alberto, López-Menéndez Celia, Moreno-Bueno Gema, Santos Vanesa, Vázquez-Naharro Alberto, Santamaria Patricia G, Morales Saleta, Dubus Pierre R, Muinelo-Romay Laura, López-López Rafael, Tung Jason C, Weaver Valerie M, Portillo Francisco, Cano Amparo, ;2017;Cancer research;77;5846-5859; 28720577