- hyperactivity / IMPC
- abnormal gait / IMPC
- abnormal locomotor behavior / IMPC
- abnormal behavior / IMPC
- decreased grip strength / IMPC
- decreased thigmotaxis / IMPC
- decreased fasting circulating glucose level / IMPC
- decreased anxiety-related response / IMPC
- increased exploration in new environment / IMPC
B6(Cg)-Cacna1btm1.1Arte/H
| Status | Available to order |
| EMMA ID | EM:13038 |
| Citation information | RRID:IMSR_EM:13038 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6(Cg)-Cacna1btm1.1Arte/H |
| Alternative name | CaV2.2_HA Knockin |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Cacna1bKI-HA |
| Gene/Transgene symbol | Cacna1b |
Information from provider
| Provider | Annette Dolphin |
| Provider affiliation | NPP, UCL |
| Genetic information | Constitutive knock-in of a 2xHA tag in the Cacna1b (CaV2.2) gene. |
| Phenotypic information | Homozygous:Homozygous CaV2.2_HA knock-in mice are not different phenotypically from wild-type mice but provide a tool to visualise endogenous CaV2.2 channels.Heterozygous:Heterozygous CaV2.2_HA knock-in mice are not different phenotypically from wild-type mice |
| Breeding history | Mutant mice generated by TaconicArtemis in 2014 and backcrossed to wild-type C57BL/6J several times since. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Undetermined early-onset epileptic encephalopathy / Orphanet_442835
IMPC phenotypes (gene matching)
MGI phenotypes (gene matching)
- hypertension / MGI
- increased aggression towards mice / MGI
- decreased anxiety-related response / MGI
- hyperactivity / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- decreased startle reflex / MGI
- abnormal sleep pattern / MGI
- abnormal lipid level / MGI
- abnormal hypothalamus secretion / MGI
- increased thermal nociceptive threshold / MGI
- decreased chemically-elicited antinociception / MGI
- abnormal learning/memory/conditioning / MGI
- abnormal sensory capabilities/reflexes/nociception / MGI
- abnormal nervous system electrophysiology / MGI
- alcohol aversion / MGI
- increased heart rate / MGI
- decreased circulating triglyceride level / MGI
- decreased circulating glucagon level / MGI
- decreased circulating insulin level / MGI
- abnormal discrimination learning / MGI
- abnormal conditioned taste aversion behavior / MGI
- abnormal excitatory postsynaptic potential / MGI
- abnormal inhibitory postsynaptic currents / MGI
- impaired social transmission of food preference / MGI
- abnormal frequency of paradoxical sleep / MGI
- abnormal single cell response / MGI
- abnormal summary potential / MGI
- abnormal channel response / MGI
- decreased alcohol consumption / MGI
- nervous system phenotype / MGI
- abnormal synaptic transmission / MGI
- abnormal sympathetic nervous system physiology / MGI
- abnormal baroreceptor physiology / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- improved glucose tolerance / MGI
- homeostasis/metabolism phenotype / MGI
- growth/size/body region phenotype / MGI
- endocrine/exocrine gland phenotype / MGI
- behavior/neurological phenotype / MGI
- hyporesponsive to tactile stimuli / MGI
- decreased susceptibility to diet-induced obesity / MGI
- decreased circulating leptin level / MGI
- abnormal long term spatial reference memory / MGI
- increased chemical nociceptive threshold / MGI
- abnormal miniature inhibitory postsynaptic currents / MGI
- fragmentation of sleep/wake states / MGI
- impaired conditioned place preference behavior / MGI
- abnormal behavioral response to xenobiotic / MGI
- enhanced behavioral response to alcohol / MGI
- impaired behavioral response to alcohol / MGI
- postnatal lethality, incomplete penetrance / MGI
- preweaning lethality, incomplete penetrance / MGI
Literature references
- Ablation of α2δ-1 inhibits cell-surface trafficking of endogenous N-type calcium channels in the pain pathway in vivo.;Nieto-Rostro Manuela, Ramgoolam Krishma, Pratt Wendy S, Kulik Akos, Dolphin Annette C, ;2018;Proceedings of the National Academy of Sciences of the United States of America;115;E12043-E12052; 30487217
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