IMPC phenotypes (gene matching)
B6N.Cg-Fustm3.1(FUS)Emcf/H
| Status | Available to order |
| EMMA ID | EM:13072 |
| Citation information | RRID:IMSR_EM:13072 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N.Cg-Fustm3.1(FUS)Emcf/H |
| Alternative name | C57BL/6NTac-Fus tm1.1(FUS)Emcf/H |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Fustm3.1(FUS)Emcf |
| Gene/Transgene symbol | Fus |
Information from provider
| Provider | Elizabeth Fisher |
| Provider affiliation | Mammalian Genetics Unit, MRC Harwell Institute |
| Additional owner | This strain is co-owned by UCL and MRC Harwell |
| Genetic information | Mice carry the human fused in sarcoma (FUS) gene at the endogenous Fus locus. The Fus gene has been humanised (human orthologous sequence replacing mouse sequence), starting from the ATG start codon and including introns and 3' UTR. |
| Phenotypic information | Homozygous:Homozygous mice are viable, fertile and produced at normal mendelian ratios. Survival is normal up to 18 months. No obvious motor, or other, phenotype.Heterozygous:Heterozygous mice are viable, fertile, and produced at normal mendelian ratios. Survival is normal up to 18 months. No obvious motor, or other, phenotype. |
| Breeding history | Targeting was performed in 129 R1 ES cells. Following germ-line transmission in mice, were modified and used for implantation. The line has now been backcrossed 7 times onto C57BL/6N. Further backcrosses are ongoing. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Amyotrophic lateral sclerosis / Orphanet_803
- Juvenile amyotrophic lateral sclerosis / Orphanet_300605
MGI phenotypes (gene matching)
- small thymus / MGI
- motor neuron degeneration / MGI
- decreased motor neuron number / MGI
- abnormal neuromuscular synapse morphology / MGI
- small testis / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal gait / MGI
- abnormal suckling behavior / MGI
- impaired limb coordination / MGI
- increased mortality induced by gamma-irradiation / MGI
- postnatal growth retardation / MGI
- reduced female fertility / MGI
- male infertility / MGI
- decreased litter size / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- lymphoid hypoplasia / MGI
- abnormal immunoglobulin level / MGI
- no phenotypic analysis / MGI
- abnormal chromosome morphology / MGI
- aneuploidy / MGI
- chromosome breakage / MGI
- decreased lymphocyte cell number / MGI
- decreased B cell number / MGI
- abnormal male meiosis / MGI
- abnormal hippocampus pyramidal cell morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI