IMPC phenotypes (gene matching)
B6.129S6-Marcotm1Ktry/H
| Status | Available to order |
| EMMA ID | EM:13142 |
| Citation information | RRID:IMSR_EM:13142 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S6-Marcotm1Ktry/H |
| Alternative name | Marco knockout mice |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Marcotm1Ktry |
| Gene/Transgene symbol | Marco |
Information from provider
| Provider | Karl Tryggvason |
| Provider affiliation | Duke-NUS Medical School |
| Additional owner | Prof. Siamon Gordon, Department of Pathology, University of Oxford, United Kingdom |
| Genetic information | Marco gene was deleted by homologous recombination. |
| Phenotypic information | Homozygous:Lack the MARCO protein in selected macrophage populations. Defective spleen marginal zone architecture. Unable to induce T independent antigen response. Susceptible to variety of bacterial fungal and viral infection.Heterozygous:Same as wild-type. |
| Breeding history | Marco knock-out mice were backcrossed to C57BL/6J line for 10 generations and the established homozygous line has been maintained as brother x sister mate within Univ. of Oxford facility. They breed just as good as the background strain with average litter sizes of 5/7 pups and the health status has remained consistent for many years. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- impaired macrophage phagocytosis / MGI
- increased inflammatory response / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal dendritic cell physiology / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- increased interferon-gamma secretion / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal dendritic cell chemotaxis / MGI
Literature references
- Defective microarchitecture of the spleen marginal zone and impaired response to a thymus-independent type 2 antigen in mice lacking scavenger receptors MARCO and SR-A.;Chen Yunying, Pikkarainen Timo, Elomaa Outi, Soininen Raija, Kodama Tatsuhiko, Kraal Georg, Tryggvason Karl, ;2005;Journal of immunology (Baltimore, Md. : 1950);175;8173-80; 16339556
- MARCO, an innate activation marker of macrophages, is a class A scavenger receptor for Neisseria meningitidis.;Mukhopadhyay Subhankar, Chen Yunying, Sankala Marko, Peiser Leanne, Pikkarainen Timo, Kraal Georg, Tryggvason Karl, Gordon Siamon, ;2006;European journal of immunology;36;940-9; 16525990
- SR-A/MARCO-mediated ligand delivery enhances intracellular TLR and NLR function, but ligand scavenging from cell surface limits TLR4 response to pathogens.;Mukhopadhyay Subhankar, Varin Audrey, Chen Yunying, Liu Baoying, Tryggvason Karl, Gordon Siamon, ;2011;Blood;117;1319-28; 21098741