STOCK Tg(Tcra5CC7,Tcrb5CC7)IWep/WepH
| Status | Available to order |
| EMMA ID | EM:13156 |
| Citation information | RRID:IMSR_EM:13156 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tg(Tcra5CC7,Tcrb5CC7)IWep/WepH |
| Alternative name | B10.BR 5C.C7 TCRtg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tcra5CC7,Tcrb5CC7)IWep |
| Gene/Transgene symbol | Tg(Tcra5CC7,Tcrb5CC7)IWep |
Information from provider
| Provider | Christoph Wuelfing |
| Provider affiliation | University of Bristol |
| Additional owner | rights have been transferred to MRC Harwell by MTA |
| Genetic information | 5C.C7 T cell receptor expressed as a transgene in the C57BL/6 MHC congenic B10.BR strain; MHC allele H2-k. Described in Seder RA et al., The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J. Exp. Med., 1992;176(4):1091-8. |
| Phenotypic information | Homozygous:Express the 5C.C7 T cell receptor on the majority of their T cells.Heterozygous:Express the 5C.C7 T cell receptor on the majority of their T cells. |
| Breeding history | Generated in the Davis laboratory at Stanford University, bred to homozygosity and maintained since. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.;Seder R A, Paul W E, Davis M M, Fazekas de St Groth B, ;1992;The Journal of experimental medicine;176;1091-8; 1328464
- Five Inhibitory Receptors Display Distinct Vesicular Distributions in Murine T Cells.;Lu Jiahe, Veler Alisa, Simonetti Boris, Raj Timsse, Chou Po Han, Cross Stephen J, Phillips Alexander M, Ruan Xiongtao, Huynh Lan, Dowsey Andrew W, Ye Dingwei, Murphy Robert F, Verkade Paul, Cullen Peter J, Wülfing Christoph, ;2023;Cells;12;; 37947636