B6.129S2-Hint2tm1Geno/Orl
| Status | Available to order |
| EMMA ID | EM:13165 |
| Citation information | RRID:IMSR_EM:13165 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-Hint2tm1Geno/Orl |
| Alternative name | Hint2 cond. KO |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Hint2tm1Geno |
| Gene/Transgene symbol | Hint2 |
Information from provider
| Provider | Jean-François Dufour |
| Provider affiliation | BioMedical Research DBMR, University of Bern |
| Genetic information | Floxed Hint2 gene. Deletion of exon 1 to exon 5 upon cre recombinase-mediated excision. |
| Phenotypic information | Homozygous:No phenotype without stress (in publications we reported the effect of fasting and high fat diet). Development of a fatty liver by the age of 20 weeks.Heterozygous:No sign of a phenotype if not placed under stress condition. No evidence for an of increased mortality. No evidence for reproduction problems. |
| Breeding history | Strain line in breeding for 10 years. No sign of a phenotype if not placed under stress condition. No evidence for an of increased mortality. No evidence for reproduction problems. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Literature references
- Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.;Martin Juliette, Balmer Maria L, Rajendran Saranya, Maurhofer Olivier, Dufour Jean-François, St-Pierre Marie V, ;2016;American journal of physiology. Gastrointestinal and liver physiology;310;G497-509; 26767982
- The histidine triad nucleotide-binding protein 2 (HINT-2) positively regulates hepatocellular energy metabolism.;Rajasekaran Raviprasadh, Felser Andrea, Nuoffer Jean-Marc, Dufour Jean-François, St-Pierre Marie V, ;2018;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;32;5143-5161; 29913563
- Characterization of the effect of the mitochondrial protein Hint2 on intracellular Ca(2+) dynamics.;Ndiaye Dieynaba, Collado-Hilly Mauricette, Martin Juliette, Prigent Sylvie, Dufour Jean-François, Combettes Laurent, Dupont Geneviève, ;2013;Biophysical journal;105;1268-75; 24010670
- Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis.;Lenglet Sébastien, Antigny Fabrice, Vetterli Laurène, Dufour Jean-François, Rossier Michel F, ;2008;Endocrinology;149;5461-9; 18653718
- Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma.;Martin Juliette, Magnino Fabrice, Schmidt Karin, Piguet Anne-Christine, Lee Ju-Seog, Semela David, St-Pierre Marie V, Ziemiecki Andrew, Cassio Doris, Brenner Charles, Thorgeirsson Snorri S, Dufour Jean-François, ;2006;Gastroenterology;130;2179-88; 16762638
- Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function.;Martin Juliette, Maurhofer Olivier, Bellance Nadège, Benard Giovanni, Graber Franziska, Hahn Dagmar, Galinier Anne, Hora Caroline, Gupta Anirudh, Ferrand Gisèle, Hoppeler Hans, Rossignol Rodrigue, Dufour Jean-François, St-Pierre Marie V, ;2013;Hepatology (Baltimore, Md.);57;2037-48; 22961760