B6.129S7-Il7rtm1Imx/Orl
| Status | Available to order |
| EMMA ID | EM:13195 |
| Citation information | RRID:IMSR_EM:13195 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S7-Il7rtm1Imx/Orl |
| Alternative name | IL7RKO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Il7rtm1Imx |
| Gene/Transgene symbol | Il7r |
Information from provider
| Provider | Sophie Ezine |
| Provider affiliation | INEM UMR-S1151, CNRS UMR 8253, Faculté de Médecine Necker |
| Additional owner | Jacques Peschon, Center for Infectious Disease Research, Seattle, WA, USA. |
| Genetic information | A neomycin resistance cassette was inserted into exon 3 of the gene |
| Phenotypic information | Homozygous:Newborn and young adult homozygous mutant mice have dramatically reduced thymic and splenic lymphoid cellularity in both B and T cell compartments.Heterozygous:Nothing |
| Breeding history | More than 10 backcrosses to C57BL/6. Now available as a B6 congenic. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Omenn syndrome / Orphanet_39041
- T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency / Orphanet_169154
Literature references
- Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.;Peschon J J, Morrissey P J, Grabstein K H, Ramsdell F J, Maraskovsky E, Gliniak B C, Park L S, Ziegler S F, Williams D E, Ware C B, Meyer J D, Davison B L, ;1994;The Journal of experimental medicine;180;1955-60; 7964471