KREIS/HgIeg

Status

Available to order

EMMA IDEM:01320
Citation informationRRID:IMSR_EM:01320 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameKREIS/HgIeg
Alternative namekreisler
Strain typeInduced Mutant Strains : Radiation-induced
Allele/Transgene symbolMafbkr
Gene/Transgene symbolMafb

Information from provider

ProviderPaula Hertwig
Provider affiliationUniversitätsklinikum Halle (Saale), Martin-Luther-Universität Halle-Wittenberg
Genetic informationX-ray induced (15Gy).
Phenotypic informationHomozygous adults show deafness and abnormal circling behavior, gross malformation of the inner ear and lack of two rhombomers of the hindbrain.
Breeding historyNot backcrossed, currently inbred.
References
  • Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes.;Manzanares M, Cordes S, Ariza-McNaughton L, Sadl V, Maruthainar K, Barsh G, Krumlauf R, ;1999;Development (Cambridge, England);126;759-69; 9895323
  • The role of kreisler in segmentation during hindbrain development.;Manzanares M, Trainor P A, Nonchev S, Ariza-McNaughton L, Brodie J, Gould A, Marshall H, Morrison A, Kwan C T, Sham M H, Wilkinson D G, Krumlauf R, ;1999;Developmental biology;211;220-37; 10395784

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • absent endolymphatic duct / MGI
  • abnormal semicircular canal morphology / MGI
  • abnormal cell cycle / MGI
  • abnormal cell cycle checkpoint function / MGI
  • abnormal endolymphatic duct morphology / MGI
  • abnormal otic vesicle development / MGI
  • inner ear cysts / MGI
  • abnormal inner ear morphology / MGI
  • abnormal membranous labyrinth morphology / MGI
  • circling / MGI
  • hyperactivity / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • abnormal neural tube morphology / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • abnormal bony labyrinth / MGI
  • head tossing / MGI
  • abnormal hindbrain development / MGI
  • abnormal otic capsule development / MGI
  • abnormal rhombomere 4 morphology / MGI
  • abnormal rhombomere 5 morphology / MGI
  • abnormal rhombomere morphology / MGI
  • abnormal hyoid bone greater horn morphology / MGI
  • abnormal pharyngeal arch development / MGI
  • ectopic pharyngeal arch / MGI
  • ectopic bone / MGI
MGI phenotypes (gene matching)
  • abnormal inner ear morphology / MGI
  • abnormal membranous labyrinth morphology / MGI
  • absent endolymphatic duct / MGI
  • kidney cortex cysts / MGI
  • abnormal kidney development / MGI
  • kidney hemorrhage / MGI
  • abnormal rhombomere morphology / MGI
  • circling / MGI
  • hyperactivity / MGI
  • cyanosis / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • abnormal respiration / MGI
  • abnormal breathing pattern / MGI
  • respiratory failure / MGI
  • respiratory distress / MGI
  • apnea / MGI
  • abnormal kidney morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal semicircular canal morphology / MGI
  • abnormal renal tubule morphology / MGI
  • abnormal cell cycle / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • anuria / MGI
  • nervous system phenotype / MGI
  • abnormal nervous system physiology / MGI
  • abnormal cell cycle checkpoint function / MGI
  • increased renal tubule apoptosis / MGI
  • abnormal bony labyrinth / MGI
  • decreased renal glomerulus number / MGI
  • abnormal brainstem morphology / MGI
  • head tossing / MGI
  • immune system phenotype / MGI
  • increased circulating creatinine level / MGI
  • abnormal endolymphatic duct morphology / MGI
  • abnormal otic vesicle development / MGI
  • abnormal hindbrain development / MGI
  • inner ear cysts / MGI
  • fused podocyte foot processes / MGI
  • abnormal hyoid bone greater horn morphology / MGI
  • abnormal pharyngeal arch development / MGI
  • ectopic pharyngeal arch / MGI
  • abnormal otic capsule development / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • abnormal endocrine pancreas development / MGI
  • abnormal rhombomere 4 morphology / MGI
  • abnormal rhombomere 5 morphology / MGI
  • ectopic bone / MGI

Literature references

  • Conserved and distinct roles of kreisler in regulation of the paralogous Hoxa3 and Hoxb3 genes.;Manzanares M, Cordes S, Ariza-McNaughton L, Sadl V, Maruthainar K, Barsh G, Krumlauf R, ;1999;Development (Cambridge, England);126;759-69; 9895323
  • The role of kreisler in segmentation during hindbrain development.;Manzanares M, Trainor P A, Nonchev S, Ariza-McNaughton L, Brodie J, Gould A, Marshall H, Morrison A, Kwan C T, Sham M H, Wilkinson D G, Krumlauf R, ;1999;Developmental biology;211;220-37; 10395784

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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