B6.129-Rybptm1Mvi/Cnbc
| Status | Available to order |
| EMMA ID | EM:13230 |
| Citation information | RRID:IMSR_EM:13230 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Rybptm1Mvi/Cnbc |
| Alternative name | Rybptm1Mvi |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Rybptm1Mvi |
| Gene/Transgene symbol | Rybp |
Information from provider
| Provider | Miguel Vidal |
| Provider affiliation | Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas |
| Genetic information | Lox P sites inserted 5' to exon 3 and 3'-UTR sequences, spanning most coding sequences. A frt site 5' to loxP site in IVS2, remaining after deleting selection cassette |
| Phenotypic information | Homozygous:Prior to conditional inactivation no observable phenotype. Following inactivation, in the hematopoietic compartment, it follows an alteration in the relative pool size of progenitor B cellsHeterozygous:None observed |
| Breeding history | Backcrossed 5-6 times onto C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Literature references
- RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells.;Hisada Kaori, Sánchez Carmen, Endo Takaho A, Endoh Mitsuhiro, Román-Trufero Mónica, Sharif Jafar, Koseki Haruhiko, Vidal Miguel, ;2012;Molecular and cellular biology;32;1139-49; 22269950
- Role of Polycomb RYBP in Maintaining the B-1-to-B-2 B-Cell Lineage Switch in Adult Hematopoiesis.;Calés Carmela, Pavón Leticia, Starowicz Katarzyna, Pérez Claudia, Bravo Mónica, Ikawa Tomokatsu, Koseki Haruhiko, Vidal Miguel, ;2015;Molecular and cellular biology;36;900-12; 26711264