STOCK Cnn3tm1.1Hjum/Ieg
| Status | Available to order |
| EMMA ID | EM:13305 |
| Citation information | RRID:IMSR_EM:13305 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Cnn3tm1.1Hjum/Ieg |
| Alternative name | Cnn3 ki f |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Cnn3tm1.1Hjum |
| Gene/Transgene symbol | Cnn3 |
Information from provider
| Provider | Axel Schweickert |
| Provider affiliation | Universität Hohenheim |
| Genetic information | Exons 2 through 5 were replaced with a loxP site, a minigene encoding exons 2 through 7 with a GFP fusion, a polyadenylation sequence, FRT-flanked neomycin resistance cassette and a loxP site. Flp-mediated recombination removed the selection cassette. |
| Phenotypic information | Homozygous:wildtypeHeterozygous:wildtype |
| Breeding history | After arrival at Hohenheim the line was inbred for 3 generations and backcrossed 3 times to the C57BL/6J genetic background. Prior to that breeding history remains unknown. We keep the allele in a heterozygous or homozygous fashion. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6J males |
Literature references
- Cnn3 regulates neural tube morphogenesis and neuronal stem cell properties.;Junghans Dirk, Herzog Sebastian, ;2018;The FEBS journal;285;325-338; 29151265
- A Conditional Knockout Mouse Model Reveals That Calponin-3 Is Dispensable for Early B Cell Development.;Flemming Alexandra, Huang Qi-Quan, Jin Jian-Ping, Jumaa Hassan, Herzog Sebastian, ;2015;PloS one;10;e0128385; 26046660