B6.129(C)-Fasltm1.1Lest/Orl

Status

Available to order

EMMA IDEM:13306
Citation informationRRID:IMSR_EM:13306 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.129(C)-Fasltm1.1Lest/Orl
Alternative nameFas ligand KO mice (Fasl KO)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolFasltm1.1Lest
Gene/Transgene symbolFasl

Information from provider

ProviderSaoussen Karray
Provider affiliationINSERM
Genetic informationFirst Fas ligand knock-out model (Fasl KO) elaborated by S. Karray & M. Lévi-Strauss at INSERM, Paris, France. Fasl KO mice were generated by breeding the Fasl floxed mice (Fasl fl/fl) with PGK-Cre transgenic mice.
Phenotypic informationHomozygous:
Fasl KO mice develop adenopathy and splenomegaly with age

Heterozygous:
No phenotype for heterozygous mice
Breeding historyMice were bred on C57BL/6 background for at least 12 generations.
References
  • Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele.;Karray Saoussen, Kress Chantal, Cuvellier Sylvain, Hue-Beauvais Catherine, Damotte Diane, Babinet Charles, Lévi-Strauss Matthieu, ;2004;Journal of immunology (Baltimore, Md. : 1950);172;2118-25; 14764677
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France
Animals used for archivinghomozygous C57BL/6 males

Disease and phenotype information

MGI phenotypes (gene matching)
  • increased leukocyte cell number / MGI
  • increased neutrophil cell number / MGI
  • decreased granulocyte number / MGI
  • enlarged liver / MGI
  • abnormal hepatocyte morphology / MGI
  • abnormal salivary gland morphology / MGI
  • lymphoid hyperplasia / MGI
  • enlarged spleen / MGI
  • enlarged lymph nodes / MGI
  • enlarged thymus / MGI
  • demyelination / MGI
  • dermatitis / MGI
  • increased metastatic potential / MGI
  • abnormal osteoclast physiology / MGI
  • anemia / MGI
  • focal hepatic necrosis / MGI
  • skin edema / MGI
  • impaired macrophage phagocytosis / MGI
  • abnormal humoral immune response / MGI
  • decreased IgG level / MGI
  • autoimmune response / MGI
  • brain inflammation / MGI
  • eye inflammation / MGI
  • liver inflammation / MGI
  • interstitial pneumonia / MGI
  • neoplasm / MGI
  • premature death / MGI
  • abnormal definitive hematopoiesis / MGI
  • abnormal T cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal lymph node morphology / MGI
  • abnormal double-negative T cell morphology / MGI
  • increased susceptibility to bacterial infection / MGI
  • increased susceptibility to viral infection / MGI
  • abnormal T cell physiology / MGI
  • increased immunoglobulin level / MGI
  • increased IgG level / MGI
  • increased IgM level / MGI
  • increased IgA level / MGI
  • increased IgE level / MGI
  • abnormal sperm number / MGI
  • glomerulonephritis / MGI
  • decreased circulating alanine transaminase level / MGI
  • increased urine protein level / MGI
  • decreased neuron apoptosis / MGI
  • increased autoantibody level / MGI
  • abnormal sperm physiology / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • increased susceptibility to systemic lupus erythematosus / MGI
  • increased spleen weight / MGI
  • increased lymphocyte cell number / MGI
  • increased T cell number / MGI
  • decreased B cell number / MGI
  • abnormal cytotoxic T cell physiology / MGI
  • decreased cytotoxic T cell cytolysis / MGI
  • abnormal T cell proliferation / MGI
  • increased B cell proliferation / MGI
  • decreased susceptibility to injury / MGI
  • increased T cell proliferation / MGI
  • renal/urinary system phenotype / MGI
  • homeostasis/metabolism phenotype / MGI
  • cardiovascular system phenotype / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal eye electrophysiology / MGI
  • increased apoptosis / MGI
  • CNS inflammation / MGI
  • abnormal retinal nerve fiber layer morphology / MGI
  • decreased retinal ganglion cell number / MGI
  • increased liver tumor incidence / MGI
  • abnormal T cell morphology / MGI
  • abnormal retinal ganglion cell morphology / MGI
  • retinal ganglion cell degeneration / MGI
  • increased plasma cell number / MGI
  • increased germinal center B cell number / MGI
  • increased IgG1 level / MGI
  • increased IgG2a level / MGI
  • increased IgG2b level / MGI
  • increased circulating tumor necrosis factor level / MGI
  • abnormal interleukin level / MGI
  • abnormal thymus cell ratio / MGI
  • decreased hepatocyte apoptosis / MGI
  • increased histiocytic sarcoma incidence / MGI
  • abnormal NK cell physiology / MGI
  • mortality/aging / MGI
  • renal cast / MGI
  • glomerular crescent / MGI
  • increased lymphoma incidence / MGI
  • impaired humoral immune response / MGI
  • increased retinal apoptosis / MGI

Literature references

  • Complete loss of Fas ligand gene causes massive lymphoproliferation and early death, indicating a residual activity of gld allele.;Karray Saoussen, Kress Chantal, Cuvellier Sylvain, Hue-Beauvais Catherine, Damotte Diane, Babinet Charles, Lévi-Strauss Matthieu, ;2004;Journal of immunology (Baltimore, Md. : 1950);172;2118-25; 14764677

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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