IMPC phenotypes (gene matching)
129-Crmp1tm1Pako/Orl
| Status | Available to order |
| EMMA ID | EM:13307 |
| Citation information | RRID:IMSR_EM:13307 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Crmp1tm1Pako/Orl |
| Alternative name | Crmp1 Frozen |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Crmp1tm1Pako |
| Gene/Transgene symbol | Crmp1 |
Information from provider
| Provider | Jérôme HONNORAT |
| Provider affiliation | Equipe SynatAc J. Honnorat, Institut NeuroMyoGène (INMG). Inserm U1217, CNRS UMR5310 |
| Genetic information | The IRES-LacZ-neo cassette was inserted in, and replacing part of, the exon 4 of the Crmp1 gene, leading to a null mutation. http://www.informatics.jax.org/allele/MGI:3701338 |
| Phenotypic information | Homozygous:Transient alterations in granule cell proliferation, apoptosis and migration in postnatal developing cerebellum of Crmp1 -/- mice.Heterozygous:No obvious abnormalities |
| Breeding history | The Crmp1 -/- line was maintained in 129 SvE genetic background by inter crossing 129SvE Crmp1 -/- x 129SvE WT for more than 10 generations and inbred crossed for 8 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous 129/SvEv males |
Disease and phenotype information
Literature references
- Transient alterations in granule cell proliferation, apoptosis and migration in postnatal developing cerebellum of CRMP1-/- mice.;Charrier Emmanuelle, Mosinger Bedrich, Meissirel Claire, Aguera Michèle, Rogemond Véronique, Reibel Sophie, Salin Paul, Chounlamountri Naura, Perrot Valérie, Belin Marie-Françoise, Goshima Yoshio, Honnorat Jérôme, Thomasset Nicole, Kolattukudy Pappachan, ;2006;Genes to cells : devoted to molecular & cellular mechanisms;11;1337-52; 17121542