129-Dpysl5tm1Gosh/Orl
| Status | Available to order |
| EMMA ID | EM:13309 |
| Citation information | RRID:IMSR_EM:13309 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129-Dpysl5tm1Gosh/Orl |
| Alternative name | Crmp5 Frozen |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Dpysl5tm1Gosh |
| Gene/Transgene symbol | Dpysl5 |
Information from provider
| Provider | Jérôme HONNORAT |
| Provider affiliation | Equipe SynatAc J. Honnorat, Institut NeuroMyoGène (INMG). Inserm U1217, CNRS UMR5310 |
| Genetic information | The IRES-LacZ-neo cassette was inserted such that it would delete exons 3, 4 and 5, leading to a null mutation of the Crmp5 (Dpysl5) gene. http://www.informatics.jax.org/allele/MGI:4941238 |
| Phenotypic information | Homozygous:Crmp5 (Dpysl5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells.Heterozygous:no obvious abnormalities |
| Breeding history | The Crmp5 -/- line was generated and maintained in 129 SvE genetic background by intercrossing 129SvE Crmp5 -/- x 129SvE WT for more than 10 generations and inbred crossed for 12 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous 129/SvEv males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
Literature references
- CRMP5 (collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells.;Yamashita Naoya, Mosinger Bedrich, Roy Arpita, Miyazaki Mari, Ugajin Kozue, Nakamura Fumio, Sasaki Yukio, Yamaguchi Kazuhiko, Kolattukudy Pappachan, Goshima Yoshio, ;2011;The Journal of neuroscience : the official journal of the Society for Neuroscience;31;1773-9; 21289187