C57BL/6-Ptprca Tg(Tcra,Tcrb)B5Lumc/H
| Status | Available to order |
| EMMA ID | EM:13351 |
| Citation information | RRID:IMSR_EM:13351 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Ptprca Tg(Tcra,Tcrb)B5Lumc/H |
| Alternative name | LnB5 TCR Tg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(TcraLnB5,TcrbLnB5) |
| Gene/Transgene symbol | Tg(TcraLnB5,TcrbLnB5) |
Information from provider
| Provider | Thorbald van Hall |
| Provider affiliation | Leiden University |
| Genetic information | TCR transgenic mice (called hereafter LnB5 Tg mice) bearing the rearranged alpha-beta receptors of the TRH4/Db-reactive clone LnB5. |
| Phenotypic information | Homozygous:This mouse strain has Valpha3 and Vbeta8 T cell receptor-positive T cells recognising the H-2Db-presented Trh4 (ceramide synthase 5) epitope.Heterozygous:Transgenic. Heterozygous and homozygous mice have same phenotype. |
| Breeding history | Generated and bred on C57BL/6 background with congenic marker Ptprca (Ly5.1). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors.;Doorduijn Elien M, Sluijter Marjolein, Querido Bianca J, Oliveira Cláudia C, Achour Adnane, Ossendorp Ferry, van der Burg Sjoerd H, van Hall Thorbald, ;2016;The Journal of clinical investigation;126;784-94; 26784543