IMPC phenotypes (gene matching)
C3El.Cg-Gsra1Neu/Ieg
| Status | Available to order |
| EMMA ID | EM:01337 |
| Citation information | RRID:IMSR_EM:01337 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3El.Cg-Gsra1Neu/Ieg |
| Alternative name | GR 180 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Gsra1Neu |
| Gene/Transgene symbol | Gsr |
Information from provider
| Provider | Walter Pretsch |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | Deletion of exon 2 to 5 in the transcript. |
| Phenotypic information | Glutathione reductase deficiency (approximately 50% residual activity in heterozygous and approximately 2% residual activity in homozygous mutants) in blood and other organs. |
| Breeding history | C3H/El (30th generation). |
| References |
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Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hemolytic anemia due to glutathione reductase deficiency / Orphanet_90030
Literature references
- Glutathione reductase activity deficiency in homozygous Gr1a1Neu mice does not cause haemolytic anaemia.;Pretsch W, ;1999;Genetical research;73;1-5; 10218442
- Analyses of glutathione reductase hypomorphic mice indicate a genetic knockout.;Rogers Lynette K, Tamura Toshiya, Rogers Bryan J, Welty Stephen E, Hansen Thomas N, Smith Charles V, ;2004;Toxicological sciences : an official journal of the Society of Toxicology;82;367-73; 15342956