B10.Cg-H2p Tg(CD68-H2-Ab1q)#Rhd/RhdKctt

Status

Available to order

EMMA IDEM:01349
Citation informationRRID:IMSR_EM:01349 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB10.Cg-H2p Tg(CD68-H2-Ab1q)#Rhd/RhdKctt
Alternative nameMBQ
Strain typeTransgenic Strains
Allele/Transgene symbolTg(CD68-H2-Ab1q)#Rhd, H2p
Gene/Transgene symbolTg(CD68-H2-Ab1q)#Rhd, H2

Information from provider

ProviderRikard Holmdahl
Provider affiliationLund University, CMB, Section for medical inflammation reseach
Genetic informationThe MBQ (macrophage A Beta Q) strain expresses the H2 I-A q beta chain in macrophages, only. The expression is strain-independent.
Phenotypic informationNone.
Breeding historyBackcrossed to B10.P for more than 20 generations.
References
  • CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species.;Pizzolla Angela, Gelderman Kyra A, Hultqvist Malin, Vestberg Mikael, Gustafsson Kenth, Mattsson Ragnar, Holmdahl Rikard, ;2011;European journal of immunology;41;403-12; 21268010

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden
Stage of embryos2-cell

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased hematocrit / MGI
  • abnormal liver physiology / MGI
  • abnormal T cell differentiation / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgM level / MGI
  • abnormal cytokine secretion / MGI
  • thyroid inflammation / MGI
  • increased autoantibody level / MGI
  • insulitis / MGI
  • increased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to autoimmune diabetes / MGI
  • decreased susceptibility to parasitic infection / MGI
  • immune system phenotype / MGI
  • periinsulitis / MGI
  • abnormal T cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI

Literature references

  • CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species.;Pizzolla Angela, Gelderman Kyra A, Hultqvist Malin, Vestberg Mikael, Gustafsson Kenth, Mattsson Ragnar, Holmdahl Rikard, ;2011;European journal of immunology;41;403-12; 21268010

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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