B6.Cg-Tg(G6PD)#Srn/Cnbc
| Status | Available to order |
| EMMA ID | EM:13519 |
| Citation information | RRID:IMSR_EM:13519 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(G6PD)#Srn/Cnbc |
| Alternative name | G6PD-Tg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(G6PD)#Srn |
| Gene/Transgene symbol | Tg(G6PD)#Srn |
Information from provider
| Provider | Manuel Serrano |
| Provider affiliation | Cellular Plasticity and Disease, Institute for Research in Biomedicine (IRB) |
| Genetic information | Transgenic mouse with moderate overexpression of human G6PD under its endogenous promoter. |
| Phenotypic information | Homozygous:We never tried to generate homozygous mice.Heterozygous:G6PD-Tg mice have constitutively increased levels of PPP activity and thereby higher levels of NADPH. G6PD-Tg mice and cells are partially protected from oxidative damage. G6PD overexpression partially protects from ageing-associated functional decline. |
| Breeding history | The founder G6PD-Tg mouse was backcrossed for 6 generations with pure C57BL/6 mice. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Literature references
- Overexpression of glucose 6 phosphate dehydrogenase preserves mouse pancreatic beta cells function until late in life.;De la Rosa Adrian, Gomez-Cabrera Mari Carmen, Vinue Angela, Gonzalez-Navarro Herminia, Sanchez-Andres Juan Vicente, Viña Jose, ;2021;Free radical biology & medicine;164;149-153; 33418115
- G6PD overexpression protects from oxidative stress and age-related hearing loss.;Bermúdez-Muñoz Jose M, Celaya Adelaida M, Hijazo-Pechero Sara, Wang Jing, Serrano Manuel, Varela-Nieto Isabel, ;2020;Aging cell;19;e13275; 33222382
- G6PD protects from oxidative damage and improves healthspan in mice.;Nóbrega-Pereira Sandrina, Fernandez-Marcos Pablo J, Brioche Thomas, Gomez-Cabrera Mari Carmen, Salvador-Pascual Andrea, Flores Juana M, Viña Jose, Serrano Manuel, ;2016;Nature communications;7;10894; 26976705