B6.129-Sdhdtm2Jlob/Cnbc
| Status | Available to order |
| EMMA ID | EM:13552 |
| Citation information | RRID:IMSR_EM:13552 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Sdhdtm2Jlob/Cnbc |
| Alternative name | B6-Sdhd-flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Sdhdtm2Jlob |
| Gene/Transgene symbol | Sdhd |
Information from provider
| Provider | José López-Barneo |
| Provider affiliation | IBiS-Universidad de Sevilla |
| Genetic information | These floxed mutant mice possess two loxP sites flanking exons 2 to 4 of the Sdhd gene and a neomycin cassette. |
| Phenotypic information | Homozygous:B6-Sdhd-flox homozygous mice do not exhibit any phenotype.Heterozygous:B6-Sdhd-flox heterozygous mice do not exhibit any phenotype. |
| Breeding history | C57BL/6J, backcrossed 10 times |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Isolated succinate-CoQ reductase deficiency / Orphanet_3208
- Carney-Stratakis syndrome / Orphanet_97286
- Hereditary pheochromocytoma-paraganglioma / Orphanet_29072
- Cowden syndrome / Orphanet_201
Literature references
- Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction.;Díaz-Castro Blanca, Pintado C Oscar, García-Flores Paula, López-Barneo José, Piruat José I, ;2012;Molecular and cellular biology;32;3347-57; 22711987