IMPC phenotypes (gene matching)
B6;129-Thrbtm1Olc/Orl
| Status | Available to order |
| EMMA ID | EM:01357 |
| Citation information | RRID:IMSR_EM:01357 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Thrbtm1Olc/Orl |
| Alternative name | TRBeta |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Thrbtm1Olc |
| Gene/Transgene symbol | Thrb |
Information from provider
| Provider | Olivier Chassande |
| Provider affiliation | CNRS -Ecole Normale Superieure de Lyon |
| Genetic information | To inactivate the Thrb (TRBeta) gene, a recombination cassette containing both a lacZ coding sequence and a NeoR gene driven by the beta-actin promoter was introduced downstream of exon 3. |
| Phenotypic information | hyperthyroxinemia, goiter, deafness, tachycardia |
| References |
|
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6 x 129 males, wild-type females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (allele matching)
- osteoporosis / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- short limbs / MGI
- short tail / MGI
- decreased body weight / MGI
- abnormal osteoclast physiology / MGI
- increased heart rate / MGI
- short tibia / MGI
- abnormal bone mineralization / MGI
- abnormal long bone epiphyseal plate morphology / MGI
- premature endochondral bone ossification / MGI
- thyroid gland hyperplasia / MGI
- increased activity of thyroid / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal bone structure / MGI
- increased compact bone thickness / MGI
- abnormal thyroid follicle morphology / MGI
- decreased circulating insulin-like growth factor I level / MGI
- increased osteoclast cell number / MGI
- increased circulating thyroid-stimulating hormone level / MGI
- digestive/alimentary phenotype / MGI
- cardiovascular system phenotype / MGI
- increased circulating thyroxine level / MGI
- increased circulating triiodothyronine level / MGI
- decreased long bone epiphyseal plate size / MGI
- decreased trabecular bone thickness / MGI
- abnormal chondrocyte physiology / MGI
- small fontanelles / MGI
MGI phenotypes (gene matching)
- abnormal cochlea morphology / MGI
- abnormal organ of Corti morphology / MGI
- organ of Corti degeneration / MGI
- osteoporosis / MGI
- premature cranial suture closure / MGI
- abnormal trabecular bone morphology / MGI
- decreased compact bone thickness / MGI
- abnormal long bone hypertrophic chondrocyte zone / MGI
- abnormal cranium morphology / MGI
- short limbs / MGI
- short tail / MGI
- enlarged pituitary gland / MGI
- small cerebellum / MGI
- abnormal cerebellar Purkinje cell layer / MGI
- abnormal Purkinje cell morphology / MGI
- decreased Purkinje cell number / MGI
- thin cerebellar molecular layer / MGI
- abnormal retinal cone cell morphology / MGI
- decreased body length / MGI
- decreased body weight / MGI
- decreased body size / MGI
- hyperactivity / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- audiogenic seizures / MGI
- abnormal osteoclast physiology / MGI
- postnatal growth retardation / MGI
- impaired synaptic plasticity / MGI
- respiratory distress / MGI
- deafness / MGI
- increased pituitary adenoma incidence / MGI
- premature death / MGI
- abnormal limb morphology / MGI
- abnormal skeleton development / MGI
- increased heart rate / MGI
- decreased vertical activity / MGI
- short tibia / MGI
- abnormal thyroid physiology / MGI
- abnormal bone mineralization / MGI
- no phenotypic analysis / MGI
- abnormal long bone epiphyseal plate morphology / MGI
- short femur / MGI
- abnormal tectorial membrane morphology / MGI
- detached tectorial membrane / MGI
- premature endochondral bone ossification / MGI
- premature intramembranous bone ossification / MGI
- thyroid gland hyperplasia / MGI
- increased activity of thyroid / MGI
- abnormal response/metabolism to endogenous compounds / MGI
- abnormal long bone epiphyseal plate proliferative zone / MGI
- abnormal bone structure / MGI
- abnormal pillar cell morphology / MGI
- abnormal pituitary hormone level / MGI
- abnormal cone electrophysiology / MGI
- increased compact bone thickness / MGI
- abnormal fetal growth/weight/body size / MGI
- cochlear hair cell degeneration / MGI
- decreased cochlear outer hair cell number / MGI
- cochlear outer hair cell degeneration / MGI
- decreased cochlear microphonics / MGI
- abnormal cochlear nerve compound action potential / MGI
- abnormal cochlear inner hair cell physiology / MGI
- abnormal cochlear outer hair cell physiology / MGI
- decreased cochlear outer hair cell electromotility / MGI
- degeneration of organ of Corti supporting cells / MGI
- short cochlear outer hair cells / MGI
- enlarged tectorial membrane / MGI
- delayed inner ear development / MGI
- abnormal thyroid follicle morphology / MGI
- decreased circulating insulin-like growth factor I level / MGI
- abnormal distortion product otoacoustic emission / MGI
- absent distortion product otoacoustic emissions / MGI
- sensorineural hearing loss / MGI
- spiral ligament degeneration / MGI
- increased osteoclast cell number / MGI
- increased circulating thyroid-stimulating hormone level / MGI
- increased thyroid-stimulating hormone level / MGI
- enlarged thyroid gland / MGI
- homeostasis/metabolism phenotype / MGI
- hearing/vestibular/ear phenotype / MGI
- digestive/alimentary phenotype / MGI
- cardiovascular system phenotype / MGI
- behavior/neurological phenotype / MGI
- abnormal circulating hormone level / MGI
- abnormal thyroid hormone level / MGI
- increased thyroxine level / MGI
- increased triiodothyronine level / MGI
- increased circulating thyroxine level / MGI
- decreased circulating thyroxine level / MGI
- increased circulating triiodothyronine level / MGI
- abnormal pituitary gland physiology / MGI
- impaired hearing / MGI
- abnormal epiphyseal plate morphology / MGI
- decreased long bone epiphyseal plate size / MGI
- increased thyrotroph cell number / MGI
- decreased trabecular bone thickness / MGI
- abnormal chondrocyte physiology / MGI
- increased thyroid carcinoma incidence / MGI
- decreased excitatory postsynaptic current amplitude / MGI
- abnormal habituation / MGI
- increased or absent threshold for auditory brainstem response / MGI
- impaired learning / MGI
- abnormal tectorial membrane striated-sheet matrix morphology / MGI
- increased thyroid gland weight / MGI
- increased cardiac cell glucose uptake / MGI
- small fontanelles / MGI
Literature references
- Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development.;Gauthier K, Chassande O, Plateroti M, Roux J P, Legrand C, Pain B, Rousset B, Weiss R, Trouillas J, Samarut J, ;1999;The EMBO journal;18;623-31; 9927422
- Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo.;Hönes G Sebastian, Rakov Helena, Logan John, Liao Xiao-Hui, Werbenko Eugenie, Pollard Andrea S, Præstholm Stine M, Siersbæk Majken S, Rijntjes Eddy, Gassen Janina, Latteyer Sören, Engels Kathrin, Strucksberg Karl-Heinz, Kleinbongard Petra, Zwanziger Denise, Rozman Jan, Gailus-Durner Valerie, Fuchs Helmut, Hrabe de Angelis Martin, Klein-Hitpass Ludger, Köhrle Josef, Armstrong David L, Grøntved Lars, Bassett J H Duncan, Williams Graham R, Refetoff Samuel, Führer Dagmar, Moeller Lars C, ;2017;Proceedings of the National Academy of Sciences of the United States of America;114;E11323-E11332; 29229863