B6.Cg-Tg(H2-Ld/H2-Dd)LD8Gja/Kctt
| Status | Available to order |
| EMMA ID | EM:01365 |
| Citation information | RRID:IMSR_EM:01365 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(H2-Ld/H2-Dd)LD8Gja/Kctt |
| Alternative name | C.B6-Tg(H2Ldalpha1/H2Ldalpha2/H2Ddalpha3)LD8 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(H2-Ld/H2-Dd)LD8Gja |
| Gene/Transgene symbol | Tg(H2-L |
Information from provider
| Provider | Petter HOGLUND |
| Provider affiliation | MTC, Karolinska Instituet |
| Genetic information | Transgenic MHC class I gene construct containing the alpha1/alpha2 domain sequences from H2-L, coupled to the alpha3 and intracellular domain sequences from H2-D. |
| Phenotypic information | No defects known. |
| Breeding history | Microinjected into CD1 x C57BL/6J and backcrossed to C57BL/6J for 7 generations. Kept homozygous by brother:sister inbreeding. |
| References |
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Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Literature references
- Alpha1/alpha2 domains of H-2D(d), but not H-2L(d), induce "missing self" reactivity in vivo--no effect of H-2L(d) on protection against NK cells expressing the inhibitory receptor Ly49G2.;Johansson M H, Höglund E, Nakamura M C, Ryan J C, Höglund P, ;1998;European journal of immunology;28;4198-206; 9862356