C.Cg-Tg(Igh-VSp6/IGHM)39Corc/Orl
| Status | Available to order |
| EMMA ID | EM:01371 |
| Citation information | RRID:IMSR_EM:01371 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C.Cg-Tg(Igh-VSp6/IGHM)39Corc/Orl |
| Alternative name | hmuSp6 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Igh-VSp6/IGHM)39Corc |
| Gene/Transgene symbol | Tg(Igh-VSp6/IGHM)39Corc |
Information from provider
| Provider | Daniel Corcos |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Genetic information | The hmuSp6 construct encodes a human immunoglobulin mu heavy chain with a mouse Sp6 variable region. |
| Phenotypic information | Expression of the hmuSp6 constructs leads to allelic exclusion of endogenous gene. B cell development is close to normal. |
| Breeding history | Backcrossed to BALB/c for at least 10 generations. Currently bred as homozygous. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Literature references
- Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein.;Corcos D, Dunda O, Butor C, Cesbron J Y, Lorès P, Bucchini D, Jami J, ;1995;Current biology : CB;5;1140-8; 8548286
- Expression of a V region-less B cell receptor confers a tolerance-like phenotype on transgenic B cells.;Corcos D, Grandien A, Vazquez A, Dunda O, Lorès P, Bucchini D, ;2001;Journal of immunology (Baltimore, Md. : 1950);166;3083-9; 11207259