IMPC phenotypes (gene matching)
B6.129S4-Ssttm1Ute/Orl
| Status | Available to order |
| EMMA ID | EM:01377 |
| Citation information | RRID:IMSR_EM:01377 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S4-Ssttm1Ute/Orl |
| Alternative name | SRIF KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ssttm1Ute |
| Gene/Transgene symbol | Sst |
Information from provider
| Provider | Jacques Epelbaum |
| Provider affiliation | U549 INSERM |
| Genetic information | Homologous recombination replacement of a part of the promoter and the first exon of the somatostatin gene, by a 129S6 mouse genomic DNA fragment followed by a PGK-neomycin selection cassette. |
| Phenotypic information | unknown |
| References |
|
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
- increased circulating corticosterone level / MGI
- abnormal motor learning / MGI
- nervous system phenotype / MGI
- increased circulating growth hormone level / MGI
- homeostasis/metabolism phenotype / MGI
- behavior/neurological phenotype / MGI
- increased circulating insulin level / MGI
- decreased circulating prolactin level / MGI
- increased circulating ghrelin level / MGI
- enlarged stomach / MGI
- abnormal gastric gland morphology / MGI
- abnormal gastric parietal cell morphology / MGI
- hyperchlorhydria / MGI
- abnormal stomach fundus morphology / MGI
MGI phenotypes (gene matching)
- increased circulating corticosterone level / MGI
- increased circulating insulin level / MGI
- no abnormal phenotype detected / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal motor learning / MGI
- abnormal inhibitory postsynaptic potential / MGI
- abnormal excitatory postsynaptic potential / MGI
- no phenotypic analysis / MGI
- increased susceptibility to age related obesity / MGI
- nervous system phenotype / MGI
- enlarged stomach / MGI
- abnormal gastric gland morphology / MGI
- abnormal gastric parietal cell morphology / MGI
- increased circulating gastrin level / MGI
- abnormal circulating pituitary hormone level / MGI
- decreased circulating prolactin level / MGI
- increased circulating growth hormone level / MGI
- decreased growth hormone level / MGI
- homeostasis/metabolism phenotype / MGI
- behavior/neurological phenotype / MGI
- immune system phenotype / MGI
- hyperchlorhydria / MGI
- abnormal stomach fundus morphology / MGI
- increased circulating ghrelin level / MGI
Literature references
- Impairment in motor learning of somatostatin null mutant mice.;Zeyda T, Diehl N, Paylor R, Brennan M B, Hochgeschwender U, ;2001;Brain research;906;107-14; 11430867