IMPC phenotypes (gene matching)
B6.129S7/Sv-Sstr2tm1Rgs/Orl
| Status | Available to order |
| EMMA ID | EM:01378 |
| Citation information | RRID:IMSR_EM:01378 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S7/Sv-Sstr2tm1Rgs/Orl |
| Alternative name | sst2 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Sstr2tm1Rgs |
| Gene/Transgene symbol | Sstr2 |
Information from provider
| Provider | Jacques Epelbaum |
| Provider affiliation | U549 INSERM |
| Genetic information | Homologous recombination replacement using a 1.2 kb somatostatin receptor 2 cDNA, cloned from a murine cDNA library, by a PGK-neomycin selection cassette |
| Phenotypic information | unknown |
| References |
|
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- increased anxiety-related response / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- decreased exploration in new environment / MGI
- increased circulating adrenocorticotropin level / MGI
- decreased vertical activity / MGI
- decreased myocardial infarction size / MGI
- abnormal synaptic glutamate release / MGI
- abnormal behavior / MGI
- abnormal brain wave pattern / MGI
- digestive/alimentary phenotype / MGI
- vision/eye phenotype / MGI
- decreased dopamine level / MGI
- abnormal retinal rod bipolar cell morphology / MGI
Literature references
- Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons.;Zheng H, Bailey A, Jiang M H, Honda K, Chen H Y, Trumbauer M E, Van der Ploeg L H, Schaeffer J M, Leng G, Smith R G, ;1997;Molecular endocrinology (Baltimore, Md.);11;1709-17; 9328352