STOCK hb/OveKcl
| Status | Available to order |
| EMMA ID | EM:13786 |
| Citation information | RRID:IMSR_EM:13786 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK hb/OveKcl |
| Alternative name | Headbobber, hb |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | hb |
| Gene/Transgene symbol | hb |
Information from provider
| Provider | Karen Steel |
| Provider affiliation | King |
| Additional owner | Dr Paul Overbeek Dr Fred Pereira, fpereira@bcm.edu |
| Genetic information | Insertional mutagenesis in a transgenic line carrying a 8 kb plasmid phbAPr-1neo, which includes a portion of the human beta actin promoter, leading to a 648 kb deletion on distal Chr7, resulting in the loss of three protein coding genes (Gpr26, Cpmx2 and Chst15). |
| Phenotypic information | Homozygous:Headbobbing, circling and deafnessHeterozygous:No obvious defect |
| Breeding history | Mice carrying the headbobber mutation were originally obtained from Dr. Paul Overbeek at the Baylor College of Medicine, Houston, Texas. Details of the genetic background are unknown, but the mutants were maintained within a closed colony over several years. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.;Buniello Annalisa, Hardisty-Hughes Rachel E, Pass Johanna C, Bober Eva, Smith Richard J, Steel Karen P, ;2013;PloS one;8;e56274; 23457544