STOCK Hmx3tm1Ebo/H[cc]

Status

Available to order

EMMA IDEM:13787
Citation informationRRID:IMSR_EM:13787 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

International strain nameSTOCK Hmx3tm1Ebo/H[cc]
Alternative nameHmx3 knockout, Hmx3-tm1Ebo
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolHmx3tm1Ebo
Gene/Transgene symbolHmx3

Information from provider

ProviderKaren Steel
Provider affiliationKing
Additional ownerDr Eva Bober and Dr Thomas Braun, Max Planck Institute for lung and heart research, Bad Nauheim, Germany.
Genetic informationTargeted inactivation of the Hmx3 (Nkx5-1) gene, described in Hadrys T. et al., 1998 (PubMed ID:9389661).
Phenotypic informationHomozygous:
Mice show headbobbing and circling.

Heterozygous:
No obvious defect.
Breeding historyMice were obtained from Dr. Eva Bober and maintained for several years by breeding within a closed colony.
References
  • Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.;Buniello Annalisa, Hardisty-Hughes Rachel E, Pass Johanna C, Bober Eva, Smith Richard J, Steel Karen P, ;2013;PloS one;8;e56274; 23457544
  • Nkx5-1 controls semicircular canal formation in the mouse inner ear.;Hadrys T, Braun T, Rinkwitz-Brandt S, Arnold H H, Bober E, ;1998;Development (Cambridge, England);125;33-9; 9389661
Homozygous fertilenot known
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased body weight / IMPC
  • hyperactivity / IMPC
  • abnormal gait / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased circulating free fatty acids level / IMPC
  • abnormal locomotor activation / IMPC
  • abnormal defecation / IMPC
  • abnormal behavior / IMPC
  • decreased prepulse inhibition / IMPC
  • decreased grip strength / IMPC
IMPC phenotypes (gene matching)
  • decreased grip strength / IMPC
  • decreased body weight / IMPC
  • decreased circulating free fatty acids level / IMPC
  • abnormal behavior / IMPC
  • decreased prepulse inhibition / IMPC
  • hyperactivity / IMPC
  • abnormal locomotor activation / IMPC
  • abnormal defecation / IMPC
  • abnormal gait / IMPC
  • decreased circulating triglyceride level / IMPC

Literature references

  • Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.;Buniello Annalisa, Hardisty-Hughes Rachel E, Pass Johanna C, Bober Eva, Smith Richard J, Steel Karen P, ;2013;PloS one;8;e56274; 23457544
  • Nkx5-1 controls semicircular canal formation in the mouse inner ear.;Hadrys T, Braun T, Rinkwitz-Brandt S, Arnold H H, Bober E, ;1998;Development (Cambridge, England);125;33-9; 9389661

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