- decreased body weight / IMPC
- hyperactivity / IMPC
- abnormal gait / IMPC
- decreased circulating triglyceride level / IMPC
- decreased circulating free fatty acids level / IMPC
- abnormal locomotor activation / IMPC
- abnormal defecation / IMPC
- abnormal behavior / IMPC
- decreased prepulse inhibition / IMPC
- decreased grip strength / IMPC
STOCK Hmx3tm1Ebo/H[cc]
| Status | Available to order |
| EMMA ID | EM:13787 |
| Citation information | RRID:IMSR_EM:13787 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Hmx3tm1Ebo/H[cc] |
| Alternative name | Hmx3 knockout, Hmx3-tm1Ebo |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Hmx3tm1Ebo |
| Gene/Transgene symbol | Hmx3 |
Information from provider
| Provider | Karen Steel |
| Provider affiliation | King |
| Additional owner | Dr Eva Bober and Dr Thomas Braun, Max Planck Institute for lung and heart research, Bad Nauheim, Germany. |
| Genetic information | Targeted inactivation of the Hmx3 (Nkx5-1) gene, described in Hadrys T. et al., 1998 (PubMed ID:9389661). |
| Phenotypic information | Homozygous:Mice show headbobbing and circling.Heterozygous:No obvious defect. |
| Breeding history | Mice were obtained from Dr. Eva Bober and maintained for several years by breeding within a closed colony. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
- decreased grip strength / IMPC
- decreased body weight / IMPC
- decreased circulating free fatty acids level / IMPC
- abnormal behavior / IMPC
- decreased prepulse inhibition / IMPC
- hyperactivity / IMPC
- abnormal locomotor activation / IMPC
- abnormal defecation / IMPC
- abnormal gait / IMPC
- decreased circulating triglyceride level / IMPC
Literature references
- Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness.;Buniello Annalisa, Hardisty-Hughes Rachel E, Pass Johanna C, Bober Eva, Smith Richard J, Steel Karen P, ;2013;PloS one;8;e56274; 23457544
- Nkx5-1 controls semicircular canal formation in the mouse inner ear.;Hadrys T, Braun T, Rinkwitz-Brandt S, Arnold H H, Bober E, ;1998;Development (Cambridge, England);125;33-9; 9389661
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