C3HeB/FeJ-Isl1Drsh/IegH
| Status | Available to order |
| EMMA ID | EM:13789 |
| Citation information | RRID:IMSR_EM:13789 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3HeB/FeJ-Isl1Drsh/IegH |
| Alternative name | Dearisch, Isl1-Drsh |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Isl1Drsh |
| Gene/Transgene symbol | Isl1 |
Information from provider
| Provider | Karen Steel |
| Provider affiliation | King |
| Additional owner | Originally detected by the ENU mutagenesis programme at the Helmholtz Zentrum Muenchen by Helmut Fuchs and Martin Hrabe de Angelis. |
| Genetic information | An ENU-induced tyrosine to cysteine (Y71C) missense mutation in the Islet1 gene. |
| Phenotypic information | Homozygous:LethalHeterozygous:Auditory brainstem responses revealed raised thresholds to sounds from as early as three weeks old. Pedigree analysis suggested a dominant but partially penetrant mode of inheritance. The middle ear of dearisch heterozygous mutants shows a thickened mucosa and cellular effusion suggesting chronic otitis media with effusion with superimposed acute infection. |
| Breeding history | This mutation was maintained by within-colony breeding over several years. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Exome sequencing identifies a missense mutation in Isl1 associated with low penetrance otitis media in dearisch mice.;Hilton Jennifer M, Lewis Morag A, Grati M'hamed, Ingham Neil, Pearson Selina, Laskowski Roman A, Adams David J, Steel Karen P, ;2011;Genome biology;12;R90; 21936904