IMPC phenotypes (gene matching)
- increased freezing behavior / IMPC
B6.129S4/Sv-Sstr1tm1Dric/Orl
| Status | Available to order |
| EMMA ID | EM:01379 |
| Citation information | RRID:IMSR_EM:01379 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S4/Sv-Sstr1tm1Dric/Orl |
| Alternative name | sst1 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Sstr1tm1Dric |
| Gene/Transgene symbol | Sstr1 |
Information from provider
| Provider | Jacques Epelbaum |
| Provider affiliation | U549 INSERM |
| Genetic information | Homologous recombination replacement of somatostatin receptor 1 coding sequence, cloned from a 129Sv murine genomic library, by a PGK-neomycin selection cassette in a reverse orientation. |
| Phenotypic information | unknown |
| References |
|
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- hypoactivity / MGI
- increased circulating HDL cholesterol level / MGI
- decreased synaptic glutamate release / MGI
- abnormal brain wave pattern / MGI
- increased circulating cholesterol level / MGI
- abnormal eye electrophysiology / MGI
- abnormal retinal apoptosis / MGI
- abnormal retinal rod bipolar cell morphology / MGI
Literature references
- Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs.;Kreienkamp H J, Akgün E, Baumeister H, Meyerhof W, Richter D, ;1999;FEBS letters;462;464-6; 10622746