C57BL/6N-Atm1Brd Isg20tm1a(KOMP)Wtsi Del(18Ctxn3-Ccdc192)1Kcl/WtsiH[cc]
| Status | Available to order |
| EMMA ID | EM:13794 |
| Citation information | RRID:IMSR_EM:13794 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Atm1Brd Isg20tm1a(KOMP)Wtsi Del(18Ctxn3-Ccdc192)1Kcl/WtsiH[cc] |
| Alternative name | Rhythm, Del(18Ctxn3-Ccdc192)1Kcl |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Del(18Ctxn3-Ccdc192)1Kcl, Isg20tm1a(KOMP)Wtsi |
| Gene/Transgene symbol | Del(18Ctxn3-Ccdc192)1Kcl, Isg20 |
Information from provider
| Provider | Karen Steel |
| Provider affiliation | Wolfson Centre for Age-Related Diseases, King |
| Genetic information | A 303kb deletion on chromosome 18, g.18:57437258_57740507del, covering eight genes, including two protein-coding genes (Ctxn3, Ccdc192), four lncRNA genes, one miRNA and one snRNA. |
| Phenotypic information | Homozygous:Mice homozygous for the rhythm allele exhibited complete deafness with circling and head bobbing, suggesting vestibular dysfunction, associated with inner ear malformation.Heterozygous:No obvious defect. |
| Breeding history | This spontaneous mutation arose in a colony carrying a targeted mutation of Isg20 (Isg20tm1a(KOMP)Wtsi), and the targeted gene may still be present in the background. The Rhythm mutation, which causes the phenotype, has been maintained within a closed colony for several years on a C57BL/6N background. |
| References |
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| Homozygous fertile | males only |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.;Lewis Morag A, Ingham Neil J, Chen Jing, Pearson Selina, Di Domenico Francesca, Rekhi Sohinder, Allen Rochelle, Drake Matthew, Willaert Annelore, Rook Victoria, Pass Johanna, Keane Thomas, Adams David J, Tucker Abigail S, White Jacqueline K, Steel Karen P, ;2022;BMC biology;20;67; 35296311