MGI phenotypes (allele matching)
B6.129P2-Nat2tm1Esim/H
| Status | Available to order |
| EMMA ID | EM:01416 |
| Citation information | RRID:IMSR_EM:01416 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Nat2tm1Esim/H |
| Alternative name | Nat2 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nat2tm1Esim |
| Gene/Transgene symbol | Nat2 |
Information from provider
| Provider | Edith Sim |
| Provider affiliation | Department of Pharmacology, University of Oxford, Mansfield Road, Oxford |
| Genetic information | A lacZ-neomycin cassette is inserted into the murine (129P2/Ola) Nat2 gene by homologous recombination. |
| Phenotypic information | None. Arylamine N-acetyltransferase (NAT) genes are polymorphic genes involved in xenobiotic metabolism and implicated in susceptibility to neural tube defects. Nat2-/- mice represent a valuable tool for modelling the role of the human NAT1 polymorphisms in embryogenesis as well as in endogenous and xenobiotic metabolism. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Generation and analysis of mice with a targeted disruption of the arylamine N-acetyltransferase type 2 gene.;Cornish V A, Pinter K, Boukouvala S, Johnson N, Labrousse C, Payton M, Priddle H, Smith A J H, Sim E, ;2003;The pharmacogenomics journal;3;169-77; 12815365