MGI phenotypes (allele matching)
- abnormal class switch recombination / MGI
B6.129S2-Igh-8tm1Aak/Orl
| Status | Available to order |
| EMMA ID | EM:01421 |
| Citation information | RRID:IMSR_EM:01421 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2-Igh-8tm1Aak/Orl |
| Alternative name | Gamma3Neo |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Igh-8tm1Aak |
| Gene/Transgene symbol | Igh-8 |
Information from provider
| Provider | Ahmed Amine KHAMLICHI |
| Provider affiliation | CNRS UMR 5089 - IPBS |
| Genetic information | Targeting construct was derived from 129 DNA. A neomycin-resistance gene was inserted between the Igamma3 (Igh-8) germline promoter and switch gamma3 sequences, leaving intact the necessary elements for accurate splicing of gamma3 transcripts. |
| Phenotypic information | Specific decreased class switching to IgG3 isotype. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
Literature references
- Germ line transcription in mice bearing neor gene downstream of Igamma3 exon in the Ig heavy chain locus.;Samara Maha, Oruc Zeliha, Dougier Hei-Lanne, Essawi Tamer, Cogné Michel, Khamlichi Ahmed Amine, ;2006;International immunology;18;581-9; 16507599