IMPC phenotypes (gene matching)
- increased heart weight / IMPC
B6.129P2-Cd9tm1Bcx/Orl
| Status | Available to order |
| EMMA ID | EM:01424 |
| Citation information | RRID:IMSR_EM:01424 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Cd9tm1Bcx/Orl |
| Alternative name | CD9ko |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd9tm1Bcx |
| Gene/Transgene symbol | Cd9 |
Information from provider
| Provider | Claude Boucheix |
| Provider affiliation | ER70 CNRS et Unite 125 Inserm |
| Genetic information | Promoter and exon 1, containing the ATG translation initiation site, were replaced by the neomycin resistance gene. |
| Phenotypic information | Severe reduction of female fertility due to a defect in gamete fusion associated with the absence of CD9 on oocyte surface. |
| Breeding history | 16 backcrosses to C57BL/6. |
| References |
|
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
Literature references
- Severely reduced female fertility in CD9-deficient mice.;Le Naour F, Rubinstein E, Jasmin C, Prenant M, Boucheix C, ;2000;Science (New York, N.Y.);287;319-21; 10634790
- CD9 gene deficiency does not affect smooth muscle cell migration and neointima formation after vascular injury in mice.;Lijnen H R, Lupu F, Collen D, Le Naour F, Boucheix C, ;2000;Thrombosis and haemostasis;83;956-61; 10896255
- Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion.;Zhu Guo-Zhang, Miller Brent J, Boucheix Claude, Rubinstein Eric, Liu Christopher C, Hynes Richard O, Myles Diana G, Primakoff Paul, ;2002;Development (Cambridge, England);129;1995-2002; 11934865
- The tetraspanin CD81 regulates the expression of CD19 during B cell development in a postendoplasmic reticulum compartment.;Shoham Tsipi, Rajapaksa Ranjani, Boucheix Claude, Rubinstein Eric, Poe Jonathan C, Tedder Thomas F, Levy Shoshana, ;2003;Journal of immunology (Baltimore, Md. : 1950);171;4062-72; 14530327
- Murine CD9 is the receptor for pregnancy-specific glycoprotein 17.;Waterhouse Roseann, Ha Cam, Dveksler Gabriela S, ;2002;The Journal of experimental medicine;195;277-82; 11805154
- Direct binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion.;Ellerman Diego A, Ha Cam, Primakoff Paul, Myles Diana G, Dveksler Gabriela S, ;2003;Molecular biology of the cell;14;5098-103; 14528020