C57BL/6NTac-Sptlc1em1H/H

Status

Available to order

EMMA IDEM:14648
Citation informationRRID:IMSR_EM:14648 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NTac-Sptlc1em1H/H
Alternative nameSPTLC1-S331F-EM1-B6N
Strain typeEndonuclease-mediated
Allele/Transgene symbolSptlc1em1H
Gene/Transgene symbolSptlc1

Information from provider

Provider Mary Lyon Centre at MRC Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
not known

Heterozygous:
None reported
Breeding historyCo-isogenic on original background
References
  • Antisense oligonucleotides reverse SPTLC1-related hereditary sensory neuropathy in a mouse model;Shunyi Ma , Museer A Lone , Hou Wang Lam , Qiang Zhang , Shuzhi Cheng , Shona Mackie , Emma Graham , Hanna Kedzior , Charalambos Demetriou , Nicole Ziak , Laura Andreoli , Simon Beggs , Stephanie Koch , Alex J Clark , David L Bennett , Thorsten Hornemann , Francesco Muntoni , Mary M Reilly , Haiyan Zhou;2026;Brain : a journal of neurology;149;2059–2071; 41124364
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • embryonic growth retardation / IMPC
  • abnormal embryo size / IMPC

Literature references

  • Antisense oligonucleotides reverse SPTLC1-related hereditary sensory neuropathy in a mouse model;Shunyi Ma , Museer A Lone , Hou Wang Lam , Qiang Zhang , Shuzhi Cheng , Shona Mackie , Emma Graham , Hanna Kedzior , Charalambos Demetriou , Nicole Ziak , Laura Andreoli , Simon Beggs , Stephanie Koch , Alex J Clark , David L Bennett , Thorsten Hornemann , Francesco Muntoni , Mary M Reilly , Haiyan Zhou;2026;Brain : a journal of neurology;149;2059–2071; 41124364

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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