B6.129S2(Cg)-Parp3tm1.2Ics/Orl
| Status | Available to order |
| EMMA ID | EM:14722 |
| Citation information | RRID:IMSR_EM:14722 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129S2(Cg)-Parp3tm1.2Ics/Orl |
| Alternative name | Parp3 knockout mice |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Parp3tm1.2Ics |
| Gene/Transgene symbol | Parp3 |
Information from provider
| Provider | Françoise Dantzer |
| Provider affiliation | Biotechnology and Cell Signaling, UMR7242, CNRS |
| Genetic information | Disruption of the Parp3 gene. The Parp3+/- mice were generated by breeding mice carrying a conditional Parp3 (flox) allele with mice expressing a ubiquitously active CMV-cre transgene. The detailed description of the generation of the Parp3 knockout mice is provided in Boehler et al. PNAS (2011) 108(7):2783-8. doi: 10.1073/pnas.1016574108. |
| Phenotypic information | Homozygous:No overt abnormal phenotype. Increased sensitivity to X irradiation in the double Parp1-/-; Parp3-/- knockout mice.Heterozygous:No overt abnormal phenotype. |
| Breeding history | Over 10 backcross to the C57BL/6 background were performed. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
Literature references
- Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.;Boehler Christian, Gauthier Laurent R, Mortusewicz Oliver, Biard Denis S, Saliou Jean-Michel, Bresson Anne, Sanglier-Cianferani Sarah, Smith Susan, Schreiber Valérie, Boussin François, Dantzer Françoise, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;2783-8; 21270334