IMPC phenotypes (gene matching)
- hyperplasia / IMPC
129S6(129S4)-Trex1tm3.1Fwpe/Fwpe
| Status | Available to order |
| EMMA ID | EM:14792 |
| Citation information | RRID:IMSR_EM:14792 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | 129S6(129S4)-Trex1tm3.1Fwpe/Fwpe |
| Alternative name | TREX1 T303P |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Trex1tm3.1Fwpe |
| Gene/Transgene symbol | Trex1 |
Information from provider
| Provider | Fred Perrino |
| Provider affiliation | Biochemistry, Wake Forest School of Medicine |
| Genetic information | Trex1 T303P mutant mice were generated on a 129S6/SvEvTac background using an allelic replacement strategy. |
| Phenotypic information | Homozygous:Colour brown, no phenotype detected.Heterozygous:Colour brown, no phenotype detected. |
| Breeding history | 10 backcrosses |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease.;Grieves Jessica L, Fye Jason M, Harvey Scott, Grayson Jason M, Hollis Thomas, Perrino Fred W, ;2015;Proceedings of the National Academy of Sciences of the United States of America;112;5117-22; 25848017