IMPC phenotypes (gene matching)
B6.Cg-Daglatm1.1Zim/Orl
| Status | Available to order |
| EMMA ID | EM:14881 |
| Citation information | RRID:IMSR_EM:14881 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Daglatm1.1Zim/Orl |
| Alternative name | B6.cg Dagla tm1Zim |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Daglatm1.1Zim |
| Gene/Transgene symbol | Dagla |
Information from provider
| Provider | Andreas Zimmer |
| Provider affiliation | Institut für Molekulare Pychiatrie |
| Genetic information | The murine Dagla gene is located at chromosome 19 and comprises 20 exons. In the B6.Cg-Daglatm1.1Zim (or Dagla fl/fl) line the first exon and a sequence encompassing about 1 kb at the 5´end of the first exon is flanked by loxP sites. Depiction of the cloning and knock-out strategy is shown in Fig.1 of Jenniches et al., Biol Psychiatry, 2015. |
| Phenotypic information | Homozygous:The B6.Cg-Dagla |
| Breeding history | 10 generations on C57BL/6J. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased body weight / MGI
- abnormal lipid level / MGI
- absent long term depression / MGI
- abnormal CNS synaptic transmission / MGI
- abnormal excitatory postsynaptic currents / MGI
- abnormal inhibitory postsynaptic currents / MGI
- increased single cell response threshold / MGI
- abnormal nervous system morphology / MGI
- decreased neuronal precursor cell number / MGI
- abnormal neuron proliferation / MGI
Literature references
- Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels.;Jenniches Imke, Ternes Svenja, Albayram Onder, Otte David M, Bach Karsten, Bindila Laura, Michel Kerstin, Lutz Beat, Bilkei-Gorzo Andras, Zimmer Andreas, ;2016;Biological psychiatry;79;858-868; 25981172