B6.129P2-S100a9tm1Hogg/H
| Status | Available to order |
| EMMA ID | EM:14892 |
| Citation information | RRID:IMSR_EM:14892 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-S100a9tm1Hogg/H |
| Alternative name | MRP-14 (S100a9) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | S100a9tm1Hogg |
| Gene/Transgene symbol | S100a9 |
Information from provider
| Provider | Nancy Hogg |
| Provider affiliation | CRUK LRI (retired) |
| Genetic information | A selection cassette containing stop codons in all three reading frames and containing the lacZ/neo sequence targeted to a unique BamH1 site was introduced immediately following the S100a9 ATG start codon in exon 2. |
| Phenotypic information | Homozygous:Black coat colour; loss of MRP-8/14 (S100a8/9) heterodimer expressed in mouse neutrophils as 10-20% soluble protein.Heterozygous:MRP-8/14 protein 50% reduction. |
| Breeding history | Backcross to generation 10. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Distinct roles for S100a8 in early embryo development and in the maternal deciduum.;Baker J R, Jeffery R, May R D, Mathies M, Spencer-Dene B, Poulsom R, Hogg N, ;2011;Developmental dynamics : an official publication of the American Association of Anatomists;240;2194-203; 22016186
- Defective chemoattractant-induced calcium signalling in S100A9 null neutrophils.;McNeill E, Conway S J, Roderick H L, Bootman M D, Hogg N, ;2007;Cell calcium;41;107-21; 16814379
- Myeloid cell function in MRP-14 (S100A9) null mice.;Hobbs Josie A R, May Richard, Tanousis Kiki, McNeill Eileen, Mathies Margaret, Gebhardt Christoffer, Henderson Robert, Robinson Matthew J, Hogg Nancy, ;2003;Molecular and cellular biology;23;2564-76; 12640137