IMPC phenotypes (gene matching)
C57BL/6N-Prkg1tm1Cya/H
| Status | Available to order |
| EMMA ID | EM:14907 |
| Citation information | RRID:IMSR_EM:14907 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Prkg1tm1Cya/H |
| Alternative name | C195S PKG |
| Strain type | Targeted Mutant Strains : Point mutation |
| Allele/Transgene symbol | Prkg1tm1Cya |
| Gene/Transgene symbol | Prkg1 |
Information from provider
| Provider | Friederike Cuello |
| Provider affiliation | Universitätsklinikum Hamburg Eppendorf |
| Genetic information | C195S PKG mutant mice express a C195S mutant form of Prkg1 (PKG1). |
| Phenotypic information | Homozygous:Homozygous mutant mice have similar basal phenotype as wild-type littermates.Heterozygous:Heterozygous mutant mice have similar basal phenotype as wild-type littermates. |
| Breeding history | Mice were sib-mated 11 times and backcrossed 2 times to C57BL/6N. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Nitroxyl Donor CXL-1020 Lowers Blood Pressure by Targeting C195 in Cyclic Guanosine-3',5'-Monophosphate-Dependent Protein Kinase I.;Kamynina Alisa, Guttzeit Sebastian, Eaton Philip, Cuello Friederike, ;2022;Hypertension (Dallas, Tex. : 1979);79;946-956; 35168371