B6J.B6NTac-Mtnr1atm1(KOMP)Vlcg/Orl
| Status | Available to order |
| EMMA ID | EM:14912 |
| Citation information | RRID:IMSR_EM:14912 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6J.B6NTac-Mtnr1atm1(KOMP)Vlcg/Orl |
| Alternative name | Mtnr1a kiki |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mtnr1atm1.1(KOMP)Vlcg |
| Gene/Transgene symbol | Mtnr1a |
Information from provider
| Provider | Marie-Paule Felder-Schmittbuhl |
| Provider affiliation | CNRS UPR3212 |
| Genetic information | We used the ES cells generated at UCDavis, (Mtnr1atm1(KOMP)Vlcg allele, C57BL/6N background), to generate recombinant mice carrying the lacZ reporter in place of the Mtnr1a (melatonin receptor 1a or melatonin receptor 1) coding sequence. The neomycin resistance cassette was removed by breeding with cre recombinase-expressing mice. |
| Phenotypic information | Homozygous:All animals are viable and healthy, with normal reproductive cycles. Upon lacZ staining they present signal in mainly the suprachiasmatic nuclei and in the pars tuberalis.Heterozygous:All animals are viable and healthy, with normal reproductive cycles. Upon lacZ staining they present signal in mainly the suprachiasmatic nuclei and in the pars tuberalis. |
| Breeding history | The mutant mice were backcrossed to the C57BL/6J background for at least 5 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
Literature references
- MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.;Klosen Paul, Lapmanee Sarawut, Schuster Carole, Guardiola Beatrice, Hicks David, Pevet Paul, Felder-Schmittbuhl Marie Paule, ;2019;Journal of pineal research;67;e12575; 30937953