IMPC phenotypes (allele matching)
B6J.B6N-Mtnr1btm1.1(KOMP)Vlcg/Orl
| Status | Available to order |
| EMMA ID | EM:14914 |
| Citation information | RRID:IMSR_EM:14914 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6J.B6N-Mtnr1btm1.1(KOMP)Vlcg/Orl |
| Alternative name | Mtnr1b KIKI |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mtnr1btm1.1(KOMP)Vlcg |
| Gene/Transgene symbol | Mtnr1b |
Information from provider
| Provider | Marie-Paule Felder-Schmittbuhl |
| Provider affiliation | CNRS UPR3212 |
| Genetic information | This strain has a lacZ knock-in in the Mtnr1b locus, replacing the whole coding sequence. Mice carrying the Mtnr1btm1(KOMP)Vlcg allele (Regeneron strategy) were initially bred with cre recombinase deleter mice at UC Davis-KOMP to remove the neoR cassette. The mouse strain C57BL/6N-Mtnr1btm1.1(KOMP)Vlcg/MbpMmucd (RRID:MMRRC_048684-UCD), was obtained from the KOMP Repository at University of California at Davis, an NIH-funded strain repository, and was donated to the KOMP Repository, originating from Kent Lloyd, UC Davis Mouse Biology Program. The original strain has been backcrossed to C57BL/6J for 8-10 generations in Strasbourg. |
| Phenotypic information | Homozygous:Mice homozygous for the lacZ knock-in are Mtrn1b knock-out but have no visible defects.Heterozygous:Mice heterozygous for the lacZ knock-in were mainly used for the mapping of melatonin receptor expression sites. |
| Breeding history | Mice initially received from UC Davis on the C57BL/6N background were backcrossed to C57BL/6J for 8-10 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Literature references
- MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.;Klosen Paul, Lapmanee Sarawut, Schuster Carole, Guardiola Beatrice, Hicks David, Pevet Paul, Felder-Schmittbuhl Marie Paule, ;2019;Journal of pineal research;67;e12575; 30937953
- Major role of MT2 receptors in the beneficial effect of melatonin on long-term recognition memory in C57BL/6J male mice.;Pistono Cristiana, Zimmermann Amandine, Morel Chloé, Herbeaux Karine, Héraud Céline, Dumont-Kientzy Stéphanie, Pevet Paul, Felder-Schmittbuhl Marie-Paule, Mathis Chantal, ;2021;Hormones and behavior;136;105076; 34634697