IMPC phenotypes (gene matching)
B6N(Cg)-Palmdtm1.2Kili/Ieg
| Status | Available to order |
| EMMA ID | EM:14923 |
| Citation information | RRID:IMSR_EM:14923 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N(Cg)-Palmdtm1.2Kili/Ieg |
| Alternative name | Palmd-tm1.2Kili (official allele design., MGI:6477926) lab. design.: Palmdk (const. Palmd-KO) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Palmdtm1.2Kili |
| Gene/Transgene symbol | Palmd |
Information from provider
| Provider | Manfred Kilimann |
| Provider affiliation | Molecular Neurobiology, MPI for Multidisciplinary Sciences |
| Genetic information | A null mutation in the palmdelphin (Palmd) gene was generated by cre-mediated deletion of exons 4-6, resulting in a frame-shift. In homozygous mice, Palmd protein expression was undetectable (detection limit about 1%). |
| Phenotypic information | Homozygous:Mice are viable, fertile, with no apparent anomalies, normal body-weight, and reach a normal age. No anomalies were detected in the phenotyping screen of the German Mouse Clinic. Detailed analysis of endothelial cells, which express a high level of Palmd protein, revealed anomalies of the actin cytoskeleton.Heterozygous:Normal. |
| Breeding history | The mutation was generated in a C57BL/6N ES cell line. Mice were subsequently backcrossed to C57BL/6N for about 10 generations. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N males |
Disease and phenotype information
Literature references
- Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium.;Sáinz-Jaspeado Miguel, Smith Ross O, Plunde Oscar, Pawelzik Sven-Christian, Jin Yi, Nordling Sofia, Ding Yindi, Aspenström Pontus, Hedlund Marie, Bastianello Giulia, Ascione Flora, Li Qingsen, Demir Cansaran Saygili, Fernando Dinesh, Daniel Geoffrey, Franco-Cereceda Anders, Kroon Jeffrey, Foiani Marco, Petrova Tatiana V, Kilimann Manfred W, Bäck Magnus, Claesson-Welsh Lena, ;2021;Circulation;144;1629-1645; 34636652