C57BL/6-Smarca4tm1Ger/Orl
| Status | Available to order |
| EMMA ID | EM:14928 |
| Citation information | RRID:IMSR_EM:14928 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Smarca4tm1Ger/Orl |
| Alternative name | Smarca4-3FTH |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Smarca4tm1Ger |
| Gene/Transgene symbol | Smarca4 |
Information from provider
| Provider | Matthieu GERARD |
| Provider affiliation | CEA Saclay, I2BC, SBIGeM |
| Genetic information | One allele of the Smarca4 gene was modified at the C-terminus by knock-in of a sequence encoding Flag and HA epitopes. The PGK-Neo cassette used for selection is present 3' of the modification. |
| Phenotypic information | Homozygous:Homozygous mice for the mutation were never obtained at birth, suggesting embryonic lethality.Heterozygous:Heterozygous mice have an apparent wild-type phenotype. |
| Breeding history | The modified Smarca4 allele has been generated using C57BL/6 ES cells, and has been kept by breeding heterozygous mutant animals with wild-type C57BL/6 partners. |
| References | None available |
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6N males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- SMARCA4-deficient sarcoma of thorax / Orphanet_466962
- Coffin-Siris syndrome / Orphanet_1465
- Familial rhabdoid tumor / Orphanet_231108
- Small cell carcinoma of the ovary / Orphanet_370396