C57BL/6J-Iap5-1full/H
| Status | Available to order |
| EMMA ID | EM:15019 |
| Citation information | RRID:IMSR_EM:15019 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Iap5-1full/H |
| Alternative name | B6J Iap5-1fullAce |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Iap5-1full |
| Gene/Transgene symbol | Iap5-1 |
Information from provider
| Provider | Anne Ferguson-Smith |
| Provider affiliation | Genetics, University of Cambridge |
| Genetic information | This strain carries the full length variant of the genetically induced epiallele, intracisternal A-particle (Iap5-1), located near to coding gene Pgm2 on chromosome 5. Iap5-1 methylation levels effect variable expression of neighbouring genes Pgm2, Rell1, Tbc1d1 and 5830416I119Rik. |
| Phenotypic information | Homozygous:Mild metabolic phenotype depending on the methylation at the IAP. Heterozygous:Mild metabolic phenotype depending on the methylation at the IAP. |
| Breeding history | These are maintained as a homozygous colony. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function.;Bertozzi Tessa M, Takahashi Nozomi, Hanin Geula, Kazachenka Anastasiya, Ferguson-Smith Anne C, ;2021;eLife;10;; 33755012