C57BL/6-Tg(Tcra,Tcrb)577Biat/Biat
| Status | Available to order |
| EMMA ID | EM:15138 |
| Citation information | RRID:IMSR_EM:15138 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(Tcra,Tcrb)577Biat/Biat |
| Alternative name | C57BL/6N-Tg(Tcra2,Tcrb7)1Bulu - Short name: TCR-S or Spiky |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tcra,Tcrb)577Biat |
| Gene/Transgene symbol | Tg(Tcra,Tcrb)577Biat |
Information from provider
| Provider | Burkhard Ludewig |
| Provider affiliation | Institut of Immunobiology, Kantonsspital St.Gallen |
| Genetic information | TCR transgenic mouse strain specific for the s598-605 peptide of the murine hepatitis virus (MHV) spike protein. |
| Phenotypic information | Homozygous:TCR transgenic mouse strain specific for the s598-605 peptide of the MHV spike protein. 70-90% of CD8 T cells are positive for valpha2 and vbeta7.Heterozygous:TCR transgenic mouse strain specific for the s598-605 peptide of the MHV spike protein. 70-90% of CD8 T cells are positive for valpha2 and vbeta7. |
| Breeding history | N6 to C57BL/6 background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | heterozygous C57BL/6N males |
Literature references
- Central Nervous System Stromal Cells Control Local CD8(+) T Cell Responses during Virus-Induced Neuroinflammation.;Cupovic Jovana, Onder Lucas, Gil-Cruz Cristina, Weiler Elke, Caviezel-Firner Sonja, Perez-Shibayama Christian, Rülicke Thomas, Bechmann Ingo, Ludewig Burkhard, ;2016;Immunity;44;622-633; 26921107